Systematic analysis of histone modification readout
نویسندگان
چکیده
منابع مشابه
Systematic analysis of histone modification readout.
To faithfully execute diverse biological programs all cells need to access and distribute their genomes in a highly organized way. In the nucleus of eukaryotic cells DNA is packed with histone proteins into chromatin. The originating nucleo-protein complex is the regulatory platform for all genetic processes. Of these, posttranslational modifications of the histone proteins play a key role as t...
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In eukaryotic cells, genomic DNAs wrap around beadlike molecules, called nucleosomes, so as to pack more compactly in the nucleus of the cell. The nucleosome is made up of four pairs of histone proteins (H2A, H2B, H3, and H4) who share a very similar structrual motif. The positioning of nucleosomes as well as the modifications of various positions of the histone proteins (such as acetylation, m...
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Accumulating evidence suggests that epigenetic aberrations play definite roles in the pathogenesis of endometriosis. These include aberrations in genomic DNA methylation, microRNA expression, and histone modification. The aberrant histone modification status and the aberrant expression of histone deacetylases, which regulate histone acetylation, in endometriosis are the focus of this review. He...
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Histone modifications are key components of chromatin packaging but whether they constitute a 'code' has been contested. We believe that the central issue is causality: are histone modifications responsible for differences between chromatin states, or are differences in modifications mostly consequences of dynamic processes, such as transcription and nucleosome remodeling? We find that inferenc...
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ژورنال
عنوان ژورنال: Mol. BioSyst.
سال: 2013
ISSN: 1742-206X,1742-2051
DOI: 10.1039/c2mb25328c